The Endocannabinoid System and Skin Conditions

Even though, most of the research on the endocannabinoid system focuses on the involvement of cannabinoids with the central nervous system and immune system. Over the past 20 years, a significant amount of research demonstrated that cannabinoids play an effective role in maintaining the several essential functions of the skin.

The endocannabinoid system comprises a variety of endogenous ligands, a transporter apparatus, a complex enzyme, and their receptors. Each and every endocannabinoid system’s component is either involved in synthesizing, transporting, releasing, or degrading the various endocannabinoid molecules throughout the body. Moreover, these molecules exhibit a cannabinoid-like role. The naturally existing cannabinoids present in our body are considered as the second class of cannabinoids- known as the phytocannabinoids. Till date, there are more than 100 different kinds of phytocannabinoids that have been identified. Amongst which the most notable and the primary active compounds are THC and CBD. Both endocannabinoids, as well as the phytocannabinoids exhibit a wide variety of different cellular targets in the human body.

An extensive amount of research is conducted over the past two decades, the various studies and research demonstrates that both endocannabinoids, as well as phytocannabinoids, exert a range of biological effects in the skin homeostasis.

Endocannabinoids and skin conditions

The cell types present in the skin, including epidermal, melanocytes, keratinocytes, fibroblasts, sebocytes, keratinocytes, sweat gland cells and a specific portion of hair follicles also host one or the other type of endocannabinoid molecules as well as receptors.

Keeping this information in mind, the researchers have also shifted their focus on having a better understanding of how endocannabinoid ligands, as well as the receptors, play a vital role in treating the skin-related disorders.




The persuasion of the endocannabinoid system on a wide variety of skin condition is not just well-documented but is also associated with the healing process.

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